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Changes in Significant Shareholders

February 9, 2007, Osaka, Japan ---- Santen Pharmaceutical Co., Ltd. announced
the changes in significant shareholders as of February 2, 2007.
1. Details of the change
On February 8, 2007, Silchester International Investors Limited filed a fund's report to the Kanto Local Finance Bureau relating to changes in significant shareholders as follows.
2. Description of Shareholder Company
(1) Name of shareholder Silchester International Investors Limited
(2) Address Time and Life Bldg. 5th floor, 1 Bruton Street, London, W1J 6TL
(3) Representative Stephen Butt, Chairman
(4) Description of business Asset Management Company
3. Number and Percentage of Voting Rights Owned by the Company

Voting rights owned by the Company

Percentage of outstanding shares

Shareholder ranking

Before
(as of September 30, 2006)

88,084

(8,808,400 shares)

10.17%

1st

After

(as of February 1, 2007)

78,972

(7,897,200 shares)

9.12%

1st

Note1. Outstanding shares were 86,781,203 as of September 30, 2006. Deducted non voting shares from total outstanding shares were 162,403.
Note2. Above numbers are based on the significant shareholdings report filed by the company and they are not confirmed real shareholding numbers.
4. Outlook for the future
Nothing in particular

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