• Please note that the above product may not be approved or available in your country. For countries with the product approved, the above information may differ slightly country to country due to conditions of approval.

Hyalein®/Hialid® 0.1%, 0.3%
ophthalmic solution (Multi-dose)

[Label for Malaysia]
[Label for Singapore]
[Label for Singapore]

Hyalein®/Hialid® 0.1%, 0.3%
Mini ophthalmic solution (Single-dose unit)

[Label for Korea]

Active Ingredients

Hyalein/Hialid/Sanlein 0.1%

[Multi-dose], Each mL contains 1 mg of purified sodium hyaluronate.
[Single-dose unit] Each bottle (0.4 mL) contains 0.4 mg of purified sodium hyaluronate.

Hyalein/Hialid/Sanlein 0.3%

[Multi-dose], Each mL contains 3 mg of purified sodium hyaluronate.
[Single-dose unit] Each bottle (0.4mL) contains 1.2mg of purified sodium hyaluronate.

Therapeutic indications

Keratoconjunctival epithelial disorder resulting from the following diseases:

  • Intrinsic diseases such as Sjögren's syndrome, Stevens-Johnson syndrome and sicca syndrome (dry eye).
  • Extrinsic diseases caused by surgery, drugs, trauma, contact lens wearing, etc.


1.Mechanism of action

Sodium hyaluronate binds to fibronectin and accelerates the adhesion and extension of epithelial cells. Sodium hyaluronate also has an excellent water-holding property because each sodium hyaluronate molecule can retain many H2O molecules.

2.Acceleration of corneal wound healing

Topical application of sodium hyaluronate ophthalmic solution accelerates the wound healing of corneal epithelium in rabbits.

3.Acceleration of corneal epithelial extension

Sodium hyaluronate accelerates the extension of corneal epithelial cells in isolated strips of cultured rabbit cornea.

4.Prevention of corneal drying

When applied to isolated strips of rabbit cornea, sodium hyaluronate is significantly more effective than artificial tears in preventing corneal drying.


1.Adverse Reactions


 5% > ≧0.1%<0.1%
HypersensitivityBlepharitis, eyelid dermatitis-
OphthalmicItching, irritation, conjunctivitis, conjunctival injection, corneal lesion such as keratitis superficialis diffusaEye discharge

2.Precautions concerning Use

  1. Route of administration: Ophthalmic use only.
  2. At the time of administration:
  1. Instruct the patient to be careful not to touch the tip of the bottle to the eye directly in order to avoid the contamination of the drug.
  2. Instruct the patient, if any other ophthalmic drug is used, to wait at least five minutes between applying this product and any other ophthalmic drug.
  3. Instruct the patient not to use this product while wearing hydrogel soft contact lenses. (Benzalkonium chloride contained in this product may be adsorbed to soft contact lenses.)

Dosage and administration

Usually, instill one drop a time to the eye 5-6 times daily. The dosage may be adjusted according to the patient's symptoms.

Pharmaceutical Form

Clear, colorless, viscous, sterile, aqueous ophthalmic solution.


Keep below 30℃

How Supplied

[Multi-dose] Plastic bottle of 5 mL
[Single-dose unit ] Plastic vials of 0.4 mL

Approved and Available in

KoreaHyalein® 0.1%, 0.3% ophthalmic solution
Hyalein® Mini 0.1%, 0.3% ophthalmic solution
SingaporeHialid® Ophthalmic Solution 0.1%
Hialid® Ophthalmic Solution 0.3%
Hialid® Mini Ophthalmic Solution 0.3%
ThailandHialid® 0.1 ophthalmic solution
VietnamDung dịch nhỏ mắt Sanlein® 0,1
Sanlein® 0.3
PhilippinesHialid® 0.1% ophthalmic solution
MalaysiaHialid® 0.1 ophthalmic solution
IndonesiaHialid® 0.1 ophthalmic solution
Hong KongHialid® 0.1 eye drops
For healthcare professionals only. Full prescribing information is available on request.
For more information, please contact your local Santen office/representative.