Efforts to Enhance Product Usability

Developing Eye Drop Containers That Help Medical Treatments

We believe that eye drop bottles are not mere containers, but essential tools for treatment. Santen has been working to create the ideal bottle form that patients find truly usable. Listening to the voices of patients and medical professionals, from every angle we will continue to seek the best design for containers, to make them even easier to press and instill, and easier for users to distinguish the contents.

History, Innovation, Voice, Future

History

What We Can Do as a Company Specializing in Ophthalmic Pharmaceuticals

Santen’s commitment to developing the ideal container originated in 1899 in Japan, when the Company launched over-the-counter eye drops: Daigaku Eye Drops. To ensure excellent usability for this product, Santen developed a glass bottle with a cork stopple. Since no other products available then allowed users to instill liquid directly from the bottle, Santen’s container, as well as the eye drops, won high acclaim. In 1962, instead of conventional glass bottles, Santen employed plastic containers for its eye drops for the first time in Japan. Subsequently, Santen introduced various advanced technologies of the time from Western countries. For instance, the Company adopted sealed “bottle packed” containers for prescription eye drops during the 1970s, and tip-and-cap type containers with transparent caps on dropper tips during the 1990s. Santen’s researchers have always been seeking ways to help users, constantly asking themselves whether its containers are truly usable for patients. As a result, in 2002 they developed Dimple Bottles, featuring Santen’s original design.

History of Santen’s Eye Drop Bottles

1899
Glass Bottles
The first eye drops in Japan were marketed in 1867. Since then, containers have been constantly improving over the past century. Santen used glass bottles for its first eye drops.
Glass Bottles
1962
Plastic Containers
As soon as plastics became a popular material for daily utensils, Santen developed plastic containers for its eye drops. Super Sante, Japan’s first eye drops in plastic containers, became a great hit thanks to how much easier they were to carry and to administer. The use of plastic containers was regarded as a “revolution in eye drop container design.”
Plastic Containers
1977
“bottle packed” Eye Drops
To improve the safety of sterile eye drops, for the first time in Japan, Santen introduced the Blow/Fill/Seal (“bottle pack”) production system developed in Germany. This enabled container molding, solution filling, and sealing in a continuous process in a sterile, enclosed environment. Since the “bottle packed” containers had no spout openings when they were supplied to patients, this freed users from any concern about bacteria.
“bottle
1992
Tip-and-Cap
Santen introduced a tip-and-cap technology developed in the United States by improving the Blow/Fill/Seal system. In the new system, instead of providing a spout opening in the bottle body, each bottle has a dropper tip covered by a transparent cap, which keeps the container sealed tightly.
Tip-and-Cap
2002
Dimple Bottles
Santen developed its original Dimple Bottle design after thorough studies of the ideal shape for containers in terms of usability. For instance, the new design makes it easier to hold the bottle, to remove the shrink film label, and to instill the solution.
Dimple Bottles

Innovation

Developing the Ideal Container-Easy to Distinguish, Handle, and Administer

Dimple Bottles have been developed in pursuit of a simple design, under the slogan: Dimple Is Simple. As compared with conventional containers, the new bottles are easier to distinguish, handle, and administer. The most outstanding feature of the new containers is the dimples on both sides. The dimples, whose shape fits the fingertips, make the container easy to hold. By pressing the sides gently, users can instill a fixed amount of liquid from the beginning to the end. The cap also has a design making it easy to grip and open with little force. Since eye drops are used on a daily basis, Santen has sought a universal design that allows any user to hold and use the products easily. Moreover, to enhance visibility, the product name is printed in larger characters on the label, and transparent slots are arranged on both sides of the bottle to facilitate checking the amount of solution remaining in the bottle. In 2008, Santen was honored with a Good Design Award in recognition of the Company’s efforts to promote universal design.

Dimple Bottles

Dimple Bottle's Features

The shrink film label with a pull-tab is easy to remove.

The shrink film label with a pull-tab is easy to remove.

The cap has a size easy to grip, and can be opened by being rotated just once.

The cap has a size easy to grip, and can be opened by being rotated just once.

The product name is displayed in larger fonts.

The product name is displayed in larger fonts.

The dimples on both sides make the container easy to hold. The bottle is also soft and easy to press.

The dimples on both sides make the container easy to hold. The bottle is also soft and easy to press.

Transparent slots on both sides of the bottle enable users to check the amount of the remaining solution at a glance.

Transparent slots on both sides of the bottle enable users to check the amount of the remaining solution at a glance.

The nozzle has a spout opening of optimal size for instilling the right amount of solution. At the same time, the nozzle has a drip resistant design.

The nozzle has a spout opening of optimal size for instilling the right amount of solution. At the same time, the nozzle has a drip resistant design.

Voice

Developing Eye Drops Valued by Patients and Medical Professionals

Santen’s researchers developed Dimple Bottles to ensure that patients can use them easily without any safety concerns. After launching the product, Santen received favorable responses from many users. For instance, many Japanese users told us that they are pleased with Dimple Bottle since they no longer drop the container while instilling, there is no overflow from the eye, and that they can instill the liquid without pressing the bottle hard. We also received high acclaim from users in the U.S., China, and Europe. Given such favorable user responses, Santen will apply Dimple Bottles to various products for the global market, including tafluprost, a drug for glaucoma and ocular hypertension.

Voices of Medical Professionals

Each drop reaches its intended destination, preventing adverse effects around the eyes.

Dimple Bottle is incredibly user-friendly. Drops separate from the spout efficiently. Dispensing volumes and drop times are not only accurate, but consistent to the last dose. I strongly feel that this dispenser was designed for patients first and foremost. Abnormal eyelash growth, skin discoloration around the eyes and other side effects are unfortunately inevitable when using prostaglandins to treat glaucoma. But Dimple Bottle minimizes the risk of such side effects by ensuring that the right amount of solution is being dispensed consistently without any variability. it’s a sad reality that many glaucoma patients discontinue treatment in the first six months mainly due to side effects. Women particularly have an aversion toward glaucoma medication because of how it can alter their complexion. That’s why it’s crucial to have a well-designed eye drop dispenser.

Dr. Tomihiko Tanino Director Nishikamakura Tanino Eye Clinic

Easy cap removal delights patients with disabled hands.

I always keep a dimple bottle in the pocket of my white coat because it’s the best kind of container for teaching patients who visit the pharmacy how to administer their eye drops. As a pharmacist, I spend a lot of time with patients and hear many of them talk about using eye drop dispensers. For example, patients with rheumatoid arthritis tend to praise Dimple Bottle, saying that it’s the easiest to use. Cap removal is a major obstacle for patients who have difficulty using their hands, with small containers being especially hard to open. The large and extremely manageable cap on Dimple Bottle eliminates the need for patients to seek assistance from family members when taking their medication. Free from such discouragement, patients become more willing to continue their treatment. In this sense, Dimple Bottle is beneficial not only for patients, but for the people around them as well.

Dr. Junko Kikuchi Chief Executive Officer Ochanomizu Pharmacy Inc.

Feedback from our customers gave birth to dimple bottle.

Debuting in 2002, Dimple Bottle was made possible through feedback from physicians and patients. At Santen, we highly value the opinions and needs of our customers because they help us develop ever better pharmaceuticals and containers.

Future

To Enable All Patients Worldwide to More Easily View the Product

Favorable evaluations of Dimple Bottles by both patients and medical professionals have convinced us that the containers meet most user needs. On the other hand, we are still faced with various challenges. For instance, we must further work to make the containers more distinguishable for users with low vision. In addition, we must address the growing demand for preservative-free drug formulation, as well as problems relating to production costs. Regarding the requirement to make products more visible and distinguishable, we have already begun various tests in cooperation with the Japan Low Vision Society(*). We have also indicated our commitment to help patients outside Japan. Santen will continue to work to make our products more visible for low-vision patients around the world.

  • Japan Low Vision Society
    Founded in April 2000 with the aim of promoting interdisciplinary research on habilitation and rehabilitation of low vision people, as well as clinical trials. The Society also fosters friendships among its members and with members of overseas low vision societies. As of December 2011, the society has approximately 700 members.